[1]徐林锋,杨荣,甘卫东,等.TFE3易位性肾癌的预后系统评价[J].中华腔镜泌尿外科杂志(电子版),2016,10(01):58-62.[doi:10.3877/cma.j.issn.1674-3253.2016.01.016 ]
 Xu Linfeng,Yang Rong,Gan Weidong,et al.The prognosis of TFE3 translocation renal cell carcinoma: a meta-analysis[J].,2016,10(01):58-62.[doi:10.3877/cma.j.issn.1674-3253.2016.01.016 ]
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TFE3易位性肾癌的预后系统评价()
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中华腔镜泌尿外科杂志(电子版)[ISSN:1006-6977/CN:61-1281/TN]

卷:
10
期数:
2016年01期
页码:
58-62
栏目:
临床研究
出版日期:
2016-04-29

文章信息/Info

Title:
The prognosis of TFE3 translocation renal cell carcinoma: a meta-analysis
作者:
徐林锋杨荣甘卫东屈峰张古田李笑弓郭宏骞
210008南京,南京大学医学院附属鼓楼医院泌尿外科
Author(s):
Xu Linfeng Yang Rong Gan Weidong Qu FengZhang Gutian Li Xiaogong Guo Hongqian.
Department of Urology, the Affiliated Drum Tower Hospital of Medical College of Nanjing University, Nanjing 210008, China
关键词:
肾肿瘤易位预后系统评价
DOI:
10.3877/cma.j.issn.1674-3253.2016.01.016
摘要:
目的系统评价 Xp11.2易位 /TFE3基因融合性肾癌( TFE3易位性肾癌)的生物学特性。方法检索 Pubmed、Cochrane图书馆、Web of Science、CNKI、维普数据库、万方数据库并收集有关 TFE3易位性肾癌的临床疗效的对照研究文献,按预定的标准进行筛选,对纳入的文献研究进行质量评价,并提取相应指标完成 Meta分析。以转录因子 E3(TFE3)免疫组化染色阳性为 TFE3易位性肾癌的诊断标准,比较 TFE3易位性肾癌和非 TFE3易位性肾癌的分期、总生存期和无病生存期。结果共纳入 6个对照研究,合并优势比或相对危险度及 95%置信区间。总生存率和无病生存率合并相对危险度及 95%置信区间分别为 3.61 [95% CI=(1.86,7.00)],3.91 [95% CI=(2.36,6.48)],肿瘤分期的合并优势比及 95%置信区间为 4.00 [95% CI=(2.04,7.81)]。TFE3易位性肾癌明显比非 TFE3易位性肾癌病理分期高。对 TFE3易位性肾癌及非 TFE3易位性肾癌的生存曲线进行 log rank检验,显示 TFE3易位性肾癌的预后明显较差( P=0.004和 P=0.005)。结论 TFE3易位性肾癌预后明显差于非 TFE3易位性肾癌。

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备注/Memo

备注/Memo:
基金项目:江苏省自然科学基金面上项目( BK20131281),国家自然科学基金面上项目( 21377052)
通讯作者:甘卫东,Email:gwd@nju.edu.cn
更新日期/Last Update: 1900-01-01