[1]李茂胤,钟文文,王德娟,等.盐酸利多卡因对猪灌注模型中肾盂压力的影响[J].中华腔镜泌尿外科杂志(电子版),2017,11(02):129-133.[doi:10.3877/cma.j.issn.1674-3253.2017.02.013 ]
　Li Maoyin,Zhong Wenwen,Wang Dejuan,et al.Effect of endoluminal lignocaine irrigation on renal pelvic pressure in a porcine model of intrapelvic perfusion[J].,2017,11(02):129-133.[doi:10.3877/cma.j.issn.1674-3253.2017.02.013 ]
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盐酸利多卡因对猪灌注模型中肾盂压力的影响()
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中华腔镜泌尿外科杂志(电子版)[ISSN:1006-6977/CN:61-1281/TN]

卷:
11
期数:
2017年02期
页码:
129-133
栏目:
实验研究
出版日期:
2017-04-30

文章信息/Info

Title:
Effect of endoluminal lignocaine irrigation on renal pelvic pressure in a porcine model of intrapelvic perfusion
作者:
李茂胤; 钟文文; 王德娟; 黄文涛; 胡成; 李科; 邱剑光
510630广州，中山大学附属第三医院泌尿外科
Author(s):
Li Maoyin;  Zhong Wenwen;  Wang Dejuan;  Huang Wentao;  Hu Cheng;  Li Ke;  Qiu Jianguang.
Department of Urology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
关键词:
盐酸利多卡因; 肾盂压力; 猪
DOI:
10.3877/cma.j.issn.1674-3253.2017.02.013
摘要:
目的探讨 1%的盐酸利多卡因在不同灌注流速下对肾盂压力的影响。方法建立动物模型并随机将猪 5只（肾脏 10个）分为 A组（灌注利多卡因）和 B组（灌注生理盐水），其中一肾分至 A组，那么另一肾自动分至 B组。测量基础肾盂压力 5 min后，灌注实验分为 3个阶段，阶段 1：两组均以 8 ml/min的速率灌注生理盐水 5 min。阶段 2：A组以 8 ml/min的速率灌注 1%的盐酸利多卡因 5 min，而 B组以生理盐水替代。阶段 3：两组均依次以 8 ml/min、16 ml/min、24 ml/min的速率各灌注生理盐水 5 min。实验全程均监测肾盂压力值、心率和呼吸频率。结果阶段 1时 A、B两组的基础肾盂压力分别为（ 12±4）和（ 13±6）cmH2O（1 cmH2O=0.098 kPa）（P>0.05）。两组均灌注 8ml/min生理盐水时的肾盂压力分别为（ 51±12）和（ 54±16）cmH2O（P>0.05）。阶段 2：两组的肾盂压力分别为（ 47±9）和（ 52± 15）cmH2O（P>0.05）。阶段 3：两组均依次以 8 ml/min、16 ml/min、24 ml/min的速率灌注生理盐水的肾盂压力分别为（ 43±10）和（ 50±17）cmH2O（P>0.05），（49±15）和（ 61±17）cmH2O（P<0.05），（54±16）和（65±14）cmH2O（P<0.05）。整个实验过程中两组的心率和呼吸频率差异均无统计学意义。结论 1%的盐酸利多卡因可降低与灌流速率相关的肾盂压力。

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金（ 81402111）；广东省自然科学基金项目（ 2015A030313031）
通讯作者：邱剑光，Email: qjg702@qq.com
更新日期/Last Update: 2017-04-20