[1]冼土增,张俊夫,罗飞,等.多参数磁共振成像联合四基因模型提高前列腺癌早期诊断效能的临床研究[J].中华腔镜泌尿外科杂志(电子版),2018,12(03):149-153.[doi:10.3877/cma.j.issn.1674-3253.2018.03.002 ]
　Xian Tuzeng,Zhang Junfu,Luo Fei,et al.The clinical research of multi-parametric magnetic resonance imaging combined with four-gene model to improve the early diagnostic efficacy of prostate cancer[J].,2018,12(03):149-153.[doi:10.3877/cma.j.issn.1674-3253.2018.03.002 ]
点击复制

多参数磁共振成像联合四基因模型提高前列腺癌早期诊断效能的临床研究()
分享到：

中华腔镜泌尿外科杂志(电子版)[ISSN:1006-6977/CN:61-1281/TN]

卷:
12卷
期数:
2018年03期
页码:
149-153
栏目:
临床研究
出版日期:
2018-06-20

文章信息/Info

Title:
The clinical research of multi-parametric magnetic resonance imaging combined with four-gene model to improve the early diagnostic efficacy of prostate cancer
作者:
冼土增1; 张俊夫1; 罗飞2; 张添辉3; 陈征1; 江东根1; 黄群雄1; 王劲3; 高新1; 庞俊4
510630 广州，中山大学附属第三医院泌尿外科1，内分泌科2，放射科3；518107 深圳，中山大学附属第七医院泌尿外科4
Author(s):
Xian Tuzeng1;  Zhang Junfu1;  Luo Fei2;  Zhang Tianhui3;  Chen Zheng1;  Jiang Donggen1;  Huang Qunxiong1;  Wang Jin3;  Gao Xin1;  Pang Jun4.
1Department of Urology, 2Department of Endocrinology, 3Department of Radiology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; 4Department of Urology, the Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China
关键词:
前列腺癌; 诊断; 磁共振; 基因模型
DOI:
10.3877/cma.j.issn.1674-3253.2018.03.002
摘要:
目的探究多参数磁共振成像（MP-MRI）联合外周血四基因模型（ITGB5，ERG，TIMP1，TMEM176B）对前列腺癌（PCa）成像的早期诊断效能。方法建立外周血四基因 PCa诊断模型，对 363例疑似 PCa患者进行 MP-MRI检查和外周血四基因检测（结果只判定阳性或阴性），以前列腺穿刺活检或术后病理结果为金标准，计算 MP-MRI、四基因模型、MP-MRI联合四基因模型诊断 PCa的灵敏度、特异度、阳性预测值和阴性预测值。结果四基因模型单独诊断 PCa具有较高的灵敏度（99.0 %）和阴性预测值（97.9 %）。相比 MP-MRI或四基因模型单独诊断 PCa的效能，MP-MRI联合四基因模型能显著提高诊断 PCa的特异度（86.4 %）和阳性预测值（87.5 %）。结论四基因模型及 MP-MRI联合四基因模型是诊断 PCa的比较理想的方法，对 PCa的早期诊断显示出良好的临床应用前景。

参考文献/References:

[1] Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017[J]. CA Cancer J Clin, 2017, 67(1): 7-30.
[2] Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012[J]. CA Cancer J Clin, 2015, 65(2): 87-108.
[3] Zhu Y, Wang HK, Qu YY, et al. Prostate cancer in East Asia: evolving trend over the last decade[J]. Asian J Androl, 2015, 17(1): 48-57.
[4] Durmus T, Baur A, Hamm B. Multiparametric magnetic resonance imaging in the detection of prostate cancer[J]. Rofo, 2014, 186(3): 238-46
[5] Lee DJ, Ahmed HU, Moore CM, et al. Multiparametric magnetic resonance imaging in the management and diagnosis of prostate cancer: current applications and strategies[J]. Curr Urol Rep, 2014, 15(3): 390.
[6] Scheenen TW, Rosenkrantz AB, Haider MA, et al. Multiparametric magnetic resonance imaging in prostate cancer management: current status and future perspectives[J]. Invest Radiol, 2015, 50(9): 594-600.
[7] Wieczorek E, Jablonowski Z, Tomasik B, et al. MMP, VEGF and TIMP as prognostic factors in recurring bladder cancer[J]. Clin Biochem, 2015, 48(18): 1235-1240.
[8] Ross RW, Galsky MD, Scher HI, et al. A whole-blood RNA transcript-based prognostic model in men with castration-resistant prostate cancer: a prospective study[J]. Lancet Oncol, 2012, 13(11): 1105-1113.
[9] Weinreb JC, Barentsz JO, Choyke PL, et al. PI-RADS prostate imaging-reporting and data system: 2015, Version 2 [J]. Eur Urol, 2016, 69(1): 16-40.
[10] Kim JK, Hong SS, Choi YJ, et al. Wash-in rate on the basis of dynamic contrast-enhanced MRI: usefulness for prostate cancer detection and localization[J]. J Magn Reson Imaging, 2005, 22(5): 639-646.
[11] Mazzoni LN, Lucarini S, Chiti S, et al. Diffusion-weighted signalmodels in healthy and cancerous peripheral prostate tissues: comparison of outcomes obtained at different b-values[J]. J Magn Reson Imaging, 2014, 39(3): 512-518.
[12] Hatakeyama S, Yoneyama T, Tobisawa Y, et al. Recent progress and perspectives on prostate cancer biomarkers[J]. Int J Clin Oncol, 2016, 22(2): 214-221.
[13] Cullen J, Rosner IL, Brand TC, et al. A biopsy-based 17-gene genomic prostate score predicts recurrence after radical prostatectomy and adverse surgical pathology in a racially diverse population of men with clinically low-and intermediate-risk prostate cancer[J]. Eur Urol, 2015, 68(1): 123-131.
[14] Sun QP, Li LY, Chen Z, et al. Detection of TMPRSS2-ETS fusions by a multiprobe fluorescence in situ hybridization assay for the early diagnosis of prostate cancer: a pilot study[J]. J Mol Diagn, 2010, 12(5): 718-724.
[15] Gao X, Li LY, Zhou FJ, et al. ERG rearrangement for predicting subsequent cancer diagnosis in high-grade prostatic intraepithelial neoplasia and lymph node metastasis[J]. Clin Cancer Res, 2012, 18(15): 4163-4172.
[16] Metzger E, Willmann D, Mcmillan J, et al. Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation[J]. Nat Struct Mol Biol, 2016, 23(2): 132.
[17] Wang BD, Yang Q, Kristin C, et al. Androgen receptor-target genes in african american prostate cancer disparities[J]. Prostate Cancer, 2013, 2013(4): 763569.
[18] Trerotola M, Jernigan DL, Liu Q, et al.Trop-2 promotes prostate cancer metastasis by modulating β(1) integrin functions[J]. Cancer Res, 2013, 73(10): 3155-3167.
[19] Hoogland AM, Verhoef EI, Roobol MJ, et al. Validation of stem cell markers in clinical prostate cancer: α6-integrin is predictive for nonaggressive disease[J]. Prostate, 2014, 74(5): 488-496.
[20] Wang G, Jones SJ, Marra MA, et al. Identification of genes targeted by the androgen and PKA signaling pathways in prostate cancer cells[J]. Oncogene, 2006, 25(55): 7311.
[21] Castellano G, Malaponte G, Mazzarino MC, et al. Activation of the osteopontin/matrix metalloproteinase-9 pathway correlates with prostate cancer progression[J]. Clin Cancer Res, 2008, 14(22): 7470-7780.
[22] Kim Y, Ignatchenko V, Yao CQ, et al. Identification of differentially expressed proteins in direct expressed prostatic secretions of men with organ-confined versus extracapsular prostate cancer[J]. Mol Cell Proteomics, 2012, 11(12): 1870-1884.
[23] Ryu SH, Kim KH, Kim HB, et al. Oncogenic Ras-mediated downregulation of Clast1/LR8 is involved in Ras-mediated neoplastic transformation and tumorigenesis in NIH3T3 cells[J]. Cancer Sci, 2010, 101(9): 1990-1996.

相似文献/References:

[1]周建华,高新,蔡育彬,等.腹腔镜前列腺癌根治术126例3年随访结果[J].中华腔镜泌尿外科杂志(电子版),2007,(01):22.
　ZHOU Jian-hua,GAO Xin,CAI Yu-bin,et al.Results of study of 126 cases underwent laparoscopic radical Prostatectomy during three years' follow-up[J].,2007,(03):22.
[2]关健强,周少丽,龚楚链,等.腹腔镜下前列腺癌根治术中呼气末CO2分压的变化及意义[J].中华腔镜泌尿外科杂志(电子版),2008,(03):37.
　GUAN Jian-qiang,ZHOU Shao-li,GONG Chu-lian,et al.Difference between arterial and end-tidal carbon dioxide pressures in laparoscopic radical prostarectome[J].,2008,(03):37.
[3]乔鹏,邢念增.经腹膜外腹腔镜前列腺癌根治术(附9例报告)[J].中华腔镜泌尿外科杂志(电子版),2009,(01):25.
　QIAO Peng,XING Nian-zeng.Extraperitoneal laparoscopic radical prostatectomy: a report of 9 cases[J].,2009,(03):25.
[4]进展,孙其鹏,高新.TMPRSS2-ETS融合基因在前列腺癌研究的进展[J].中华腔镜泌尿外科杂志(电子版),2009,(04):354.
[5]黄海,杜涛,黄健,等.高效抑制核因子κ-B的茎环RNA基因序列的获得[J].中华腔镜泌尿外科杂志(电子版),2009,(05):444.
[6]张晓阳,王德娟,陈晓东,等.膀胱假肉瘤性肌纤维母细胞增生一例并文献复习[J].中华腔镜泌尿外科杂志(电子版),2009,(06):500.
　ZHANG Xiao-yang,WANG De-juan,CHEN Xiao-dong,et al.Pseudosarcomatous myofibroblastic proliferations: a case report and literature review[J].,2009,(03):500.
[7]高新,邱剑光,周祥福,等.腹腔镜前列腺癌根治术5年随访结果——中国单中心170例报道[J].中华腔镜泌尿外科杂志(电子版),2010,(01):2.
　GAO Xin,QIU Jian-guang,ZHOU Xiang-fu,et al.Laparoscopic radical prostatectomy:oncological and functional results of 170 patients with a minimum 5-year follow-up[J].,2010,(03):2.
[8]刘伟鹏,庞俊,李辽源,等.前列腺癌CRMP4基因启动子甲基化研究[J].中华腔镜泌尿外科杂志(电子版),2010,(01):57.
　LIU Wei-peng,PANG Jun,LI Liao-yuan,et al.A study on promoter methylation of CRMP4 in prostate cancer[J].,2010,(03):57.
[9]蒲小勇,陆敏华,高新,等.不同穿刺针数经直肠前列腺穿刺活检诊断前列腺癌的研究[J].中华腔镜泌尿外科杂志(电子版),2010,(05):347.
　PU Xiao-yong,LU Ming-hua,GAO Xin,et al.Comparative study of the different cores using transrectal prostate biopsy in diagnosis of prostate cancer[J].,2010,(03):347.
[10]刘小彭,高新,周祥福,等.耻骨后前列腺癌根治术联合内分泌治疗T3N1期前列腺癌[J].中华腔镜泌尿外科杂志(电子版),2010,(05):374.
　LIU Xiao-peng,GAO Xin,ZHOU Xiang-fu,et al.Radical prostatectomy combining with adjuvant hormone therapy for treatment of prostate cancer with pelvic lymph node metastasis[J].,2010,(03):374.
[11]孙其鹏,庞俊,李辽源,等.荧光原位杂交技术在前列腺癌诊断中的临床应用[J].中华腔镜泌尿外科杂志(电子版),2010,(01):64.
　SUN Qi-peng,PANG Jun,LI Liao-yuan,et al.Detection of TMPRSS2-ETS fusions by a multiprobe fluorescence in situ hybridization assay for the diagnosis of prostate cancer[J].,2010,(03):64.

备注/Memo

备注/Memo:
基金项目：国家自然科学基金面上项目（81772754）；广东省自然科学基金重大基础研究培育项目（2017A030308009）；广州市科技计划项目（201607010187）
通讯作者：庞俊，Email： pangjun530@sina.com
更新日期/Last Update: 2018-06-20