[1]梁毅文,黄向华,覃斌,等.肾尿酸结石患者血清中细胞因子的表达[J].中华腔镜泌尿外科杂志(电子版),2016,10(01):63-66.[doi:10.3877/cma.j.issn.1674-3253.2016.01.017 ]
　Liang Yiwen,Huang Xianghua,Qin Bin,et al.Expression of cytokines in serum of patients with renal uric acid stones[J].,2016,10(01):63-66.[doi:10.3877/cma.j.issn.1674-3253.2016.01.017 ]
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肾尿酸结石患者血清中细胞因子的表达()
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中华腔镜泌尿外科杂志(电子版)[ISSN:1006-6977/CN:61-1281/TN]

卷:
10
期数:
2016年01期
页码:
63-66
栏目:
临床研究
出版日期:
2016-04-29

文章信息/Info

Title:
Expression of cytokines in serum of patients with renal uric acid stones
作者:
梁毅文; 黄向华; 覃斌; 李长赞; 季汉初; 吴清国; 梁阳冰; 张剑歌; 黄寿付
537100贵港市人民医院泌尿外科
Author(s):
Liang Yiwen;  Huang Xianghua;  Qin Bin;  Li Changzan;  Ji Hanchu;  Wu Qinguo;  Liang Yangbin;  Zhang Jiange;  Huang Shoufu.
Department of Urology, People's Hospital of Guigang, Guangxi 537100, China
关键词:
尿酸结石; 细胞因子; 炎症
DOI:
10.3877/cma.j.issn.1674-3253.2016.01.017
摘要:
目的探讨肾脏尿酸结石患者与血液中细胞因子的关系，并寻找能够早期诊断尿酸结石的生物标志物。方法 2012年 1月至 2014年 6月贵港市人民医院采集 40例健康志愿者及 40例肾脏尿酸结石患者血液标本，通过悬浮芯片技术同步定量检测标本中 IL-1β、IL-6、MCP-1、TNF-α、 VEGF的浓度。运用统计学软件分析数据。结果两独立样本 t检验分析显示，肾结石组 IL-6、TNF-α、 MCP-1明显升高（ P<0.05）。ROC曲线显示， IL-6的 ROC曲线面积 0.934；TNF-α的 ROC曲线面积0.716；MCP-1的 ROC曲线面积 0.893；当 IL-6选择最佳诊断界值 10.595 pg/ml时，其诊断尿酸结石的灵敏度达到 0.950，特异度达到 0.900。结论肾脏尿酸结石的形成与炎症级联反应相关；血液 IL-6、 MCP-1、TNF-α是尿酸结石的高危因子，并有望成为早期诊断尿酸结石的生物标志物。

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备注/Memo

备注/Memo:
基金项目：广西科技攻关计划项目（桂科攻 12300021），贵港市科技攻关计划项目（贵科攻 1305026）
通讯作者：黄向华，Email：gghxh6668@aliyun.com
本文编辑：阮星星 李文标） 梁毅文,黄向华,覃斌,等.肾尿酸结石患者血清中细胞因子的表达[J/CD].中华腔镜泌尿外科杂志:电子版, 2016, 10(1
更新日期/Last Update: 1900-01-01