[1]杨飞,蔡佳荣,李腾成,等.生长相关蛋白-43在间质性膀胱炎患者膀胱黏膜表达的研究[J].中华腔镜泌尿外科杂志(电子版),2018,12(02):86-89.[doi:10.3877/cma.j.issn.1674-3253.2018.02.005 ]
 Yang Fei,Cai Jiarong,Li Tengcheng,et al.The expression of growth associated protein 43 in bladder tissue of patients with interstitial cystitis[J].,2018,12(02):86-89.[doi:10.3877/cma.j.issn.1674-3253.2018.02.005 ]
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生长相关蛋白-43在间质性膀胱炎患者膀胱黏膜表达的研究()
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中华腔镜泌尿外科杂志(电子版)[ISSN:1006-6977/CN:61-1281/TN]

卷:
12卷
期数:
2018年02期
页码:
86-89
栏目:
临床研究
出版日期:
2018-04-20

文章信息/Info

Title:
The expression of growth associated protein 43 in bladder tissue of patients with interstitial cystitis
作者:
杨飞蔡佳荣李腾成刘柏隆湛海伦周祥福
510530 广州,中山大学附属第三医院岭南医院泌尿外科
Author(s):
Yang Fei Cai Jiarong Li Tengcheng Liu Bolong Zhan Hailun Zhou Xiangfu.
Department of Urology, Linnan Hospital, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510530, China
关键词:
间质性膀胱炎生长相关蛋白-43症状
DOI:
10.3877/cma.j.issn.1674-3253.2018.02.005
摘要:
目的探讨生长相关蛋白 43(GAP-43)在间质性膀胱炎 /膀胱疼痛综合征(IC/BPS)患者膀胱黏膜组织中的表达情况,以及与患者症状严重程度之间的相关性。方法通过免疫组织化学法检测 GAP-43在 31例 IC/BPS患者膀胱组织中的表达情况,并通过入院时对全部病例进行症状评分(ICSI),问题评分(ICPI)和盆腔疼痛、尿频 /尿急症状评分(PUF),评估 GAP-43的表达与 IC/BPS患者症状严重性之间的相关性。结果31例 IC/BPS患者中, ICSI 13~19分,平均(16±3)分; ICPI 7~16分,平均(12±1)分。PUF 16~25分,平均(20±2)分。症状总分 37~57分,平均(46±4)分。IC/BPS患者膀胱组织中 GAP-43表达水平免疫组化评分为 0~6分,平均(5.2±0.3)分。GAP-43在IC/BPS患者膀胱组织中的表达程度与患者的症状严重程度(ICSI+ICPI、PUF、ICSI+ICPI+PUF)之间成正相关(相关系数=0.469、0.611、0.426),具有统计学意义( P=0.046、0.039、0.008)。结论 GAP-43在 IC/BPS患者膀胱组织中的表达与患者的症状严重程度成正相关,提示 GAP-43在 IC/BPS的发病机制中可能起着一定的作用。

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备注/Memo

备注/Memo:
基金项目:广东省自然科学基金(2016A030313192,2017A030310414);广东省医学科学技术研究基金项目(A2017365);国家自然科学基金(81670688)
通讯作者:周祥福,Email:xiangfuzhou@126.com
更新日期/Last Update: 2018-04-20