[1]刘柏隆陈雪莲 湛海伦 张志刚 冯智英 周祥福.间质性膀胱炎的炎症分级与神经纤维密度及临床症状的关系[J].中华腔镜泌尿外科杂志(电子版),2014,(03):171-174.
　Liu Bolong*,Chen Xuelian,Zhan Hailun,et al.The relationship among the grade of inflammation, nerve fibers density and clinical symptoms in patients with interstitial cystitis[J].,2014,(03):171-174.
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间质性膀胱炎的炎症分级与神经纤维密度及临床症状的关系()
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中华腔镜泌尿外科杂志(电子版)[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2014年03期
页码:
171-174
栏目:
临床研究
出版日期:
2014-06-30

文章信息/Info

Title:
The relationship among the grade of inflammation, nerve fibers density and clinical symptoms in patients with interstitial cystitis
作者:
刘柏隆陈雪莲 湛海伦 张志刚 冯智英 周祥福
510630广州，中山大学附属第三医院岭南医院泌尿外科（刘柏隆、陈雪莲、湛海伦、周祥福），中山大学附属第三医院病理科（张志刚、冯智英）
Author(s):
Liu Bolong*;  Chen Xuelian;  Zhan Hailun;  Zhang Zhigang;  Feng Zhiying;  Zhou Xiangfu.
Department of Urology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
关键词:
间质性膀胱炎; 炎症分级; 神经纤维密度; 症状评分
摘要:
目的 探讨间质性膀胱炎（ IC）患者膀胱组织的炎症分级与神经纤维密度及临床症状的关系，明确“炎症 -神经”相互作用在 IC致病中的作用。方法 51例 IC患者（男 9例，女 42例）均完成 VAS疼痛评分、尿频评分、尿急评分。膀胱活检标本切片后行 HE染色检测炎症分级和免疫组织化学检测 PGP9.5阳性神经纤维的表达情况。结果 IC轻度炎症组、中度炎症组、重度炎症组的 PGP9.5阳性神经纤维密度分别为（ 4.45±1.53）/cm2、（5.07±1.74）/cm2、（5.63±1.82）/cm2，三组比较差异有统计学意义（P中 /轻 =0.031，P重 /中 =0.033）；炎症分级越高， PGP9.5阳性神经纤维密度就越高（r=0.45，P<0.001）。三组患者的尿频评分比较差异有统计学意义（ P中 /轻 =0.032，P重 /中 =0.028），尿频评分与炎症分级成正相关性（ r=0.34，P=0.012）；三组患者的尿急评分比较差异有统计学意义（ P中 /轻 =0.013，P重 /中 =0.035），尿急评分与炎症分级成正相关性（ r=0.38，P=0.005）；三组患者的疼痛评分比较差异有统计学意义（ P中 /轻 =0.008，P重 /中 =0.003），疼痛评分与炎症分级成正相关（ r=0.44，P=0.001）。结论 IC患者膀胱组织中炎症分级越高， PGP9.5阳性神经纤维密度就越高；而且 IC患者的尿频、尿急、疼痛等症状的评分与膀胱组织的炎症分级成正相关性，这些结果提示“炎症 -神经 ”相互作用可能是 IC的致病机制之一。

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备注/Memo

备注/Memo:
基金项目：广东省科技计划项目（ 2011B031800077），广东省中医药局课题（ 20121142），广东省自然科技资金（S2013010016625）
通讯作者：周祥福，Email：xiangfuzhou@126.com
更新日期/Last Update: 2014-06-25