[1]刘柏隆,周祥福,杨飞,等.间质性膀胱炎各层组织中神经纤维过表达及其临床意义[J].中华腔镜泌尿外科杂志(电子版),2013,(01):50-54.
 LIU Bo-long,ZHOU Xiang-fu,YANG Fei,et al.The overexpression of nerve fibers in different layers of bladder tissues in patients with interstitial cystitis and their clinical significance[J].,2013,(01):50-54.
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间质性膀胱炎各层组织中神经纤维过表达及其临床意义()
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中华腔镜泌尿外科杂志(电子版)[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2013年01期
页码:
50-54
栏目:
出版日期:
1900-01-01

文章信息/Info

Title:
The overexpression of nerve fibers in different layers of bladder tissues in patients with interstitial cystitis and their clinical significance
作者:
刘柏隆周祥福杨飞湛海伦李文标
中山大学附属第三医院泌尿外科,广州,510630
Author(s):
LIU Bo-longZHOU Xiang-fuYANG FeiZHAN Hai-lunLI Wen-biao
关键词:
间质性膀胱炎膀胱镜检神经纤维密度症状评分
摘要:
目的 探讨间质性膀胱炎(IC)患者的膀胱各层组织神经纤维的表达情况及其与临床症状的相关性,明确其在IC致病中的意义.方法 51例IC患者为实验组(男9例,女42例),27例非IC患者的正常膀胱组织为对照组,实验组进行O'Leary-Sant、VAS评分和膀胱镜检,两组均行PGP9.5单克隆抗体免疫组化和神经纤维计数.结果 两组膀胱组织的神经纤维密度(NF-PN)分别为5.07±1.33/cm2、3.82±1.18/em2,差异具有统计学意义(P=0.001),其中两组黏膜层、黏膜下层、逼尿肌层的NF-PN的比较存在统计学差异(P值分别为0.002、0.019、0.016).O'Leary-Sant评分中的ICSI、ICPI与黏膜下层、逼尿肌层的NF-PN有关(P均<0.05),而VAS评分与黏膜层、黏膜下层的NF-PN有关(P均<0.01).结论IC患者膀胱组织的黏膜层、黏膜下层、逼尿肌层的神经纤维密度明显比对照组的高;膀胱疼痛症状与黏膜层、黏膜下层的神经纤维增多有关,而尿频、尿急症状与黏膜下层、逼尿肌层的神经纤维增多有关,表明膀胱组织的神经纤维增多可能是IC的致病因素之一.

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备注/Memo

备注/Memo:
广东省科技计划项目(201lB031800077);广东省中医药局课题(20121142)
更新日期/Last Update: 1900-01-01